| First Author | Lasheras J | Year | 2016 |
| Journal | Mol Cell Endocrinol | Volume | 430 |
| Pages | 77-88 | PubMed ID | 27062900 |
| Mgi Jnum | J:248935 | Mgi Id | MGI:6095304 |
| Doi | 10.1016/j.mce.2016.04.004 | Citation | Lasheras J, et al. (2016) Gene expression profiling in hearts of diabetic mice uncovers a potential role of estrogen-related receptor gamma in diabetic cardiomyopathy. Mol Cell Endocrinol 430:77-88 |
| abstractText | Diabetic cardiomyopathy is characterized by an abnormal oxidative metabolism, but the underlying mechanisms remain to be defined. To uncover potential mechanisms involved in the pathophysiology of diabetic cardiomyopathy, we performed a gene expression profiling study in hearts of diabetic db/db mice. Diabetic hearts showed a gene expression pattern characterized by the up-regulation of genes involved in lipid oxidation, together with an abnormal expression of genes related to the cardiac contractile function. A screening for potential regulators of the genes differentially expressed in diabetic mice found that estrogen-related receptor gamma (ERRgamma) was increased in heart of db/db mice. Overexpression of ERRgamma in cultured cardiomyocytes was sufficient to promote the expression of genes involved in lipid oxidation, increase palmitate oxidation and induce cardiomyocyte hypertrophy. Our findings strongly support a role for ERRgamma in the metabolic alterations that underlie the development of diabetic cardiomyopathy. |
