| First Author | Lee W | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 432 |
| Issue | 1 | Pages | 73-9 |
| PubMed ID | 23376064 | Mgi Jnum | J:198057 |
| Mgi Id | MGI:5495346 | Doi | 10.1016/j.bbrc.2013.01.083 |
| Citation | Lee W, et al. (2013) Anti-diabetic effect of amorphastilbol through PPARalpha/gamma dual activation in db/db mice. Biochem Biophys Res Commun 432(1):73-9 |
| abstractText | Peroxisome proliferator-activated receptors (PPARs) have been considered as desirable targets for metabolic syndrome treatments, even though their specific agonists have several side effects, including body weight gain, edema, and tissue failure. The effects of amorphastilbol (APH) on glucose- and lipid metabolism were investigated with in vitro 3T3-L1 adipocyte systems and in vivo db/db mice model. APH selectively stimulates the transcriptional activities of both PPARalpha and PPARgamma, which are able to enhance fatty acid oxidation and glucose utilization. Furthermore, APH improves glucose and lipid impairment in db/db mice. More importantly, there are no significant side effects, such as weight gain or hepatomegaly, in APH-treated animals, implying that APH do not adversely affect liver or lipid metabolism. All our data suggest that APH can be used as potential therapeutic agents against type 2 diabetes and related metabolic disorders, including obesity, by enhancing glucose and lipid metabolism. |
