| First Author | Xu N | Year | 2004 |
| Journal | Biochem Biophys Res Commun | Volume | 321 |
| Issue | 4 | Pages | 916-21 |
| PubMed ID | 15358114 | Mgi Jnum | J:91738 |
| Mgi Id | MGI:3050287 | Doi | 10.1016/j.bbrc.2004.06.180 |
| Citation | Xu N, et al. (2004) Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. Biochem Biophys Res Commun 321(4):916-21 |
| abstractText | It was previously shown that circulating levels of leptin and apolipoprotein M (apoM) correlate to each other. In this study, we examined whether plasma leptin and leptin-receptors are of importance for apoM expression in vivo. It was found that in both liver and kidney, expression of apoM was significantly lower in leptin deficient ob/ob mice and in leptin-receptor deficient db/db mice than in control mice. Furthermore, leptin administration (0.5 or 1.5 microg/g body weight) significantly increased plasma apoM levels and apoM mRNA levels in liver and in kidney in ob/ob mice. We conclude that both leptin and leptin-receptor are essential for the apoM expression, indicating that leptin is physiologically regulating apoM synthesis in vivo. |
