| First Author | Zhang Z | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 1 | Pages | 20-6 |
| PubMed ID | 21827757 | Mgi Jnum | J:179943 |
| Mgi Id | MGI:5304641 | Doi | 10.1016/j.febslet.2011.07.042 |
| Citation | Zhang Z, et al. (2012) MicroRNA-451 regulates p38 MAPK signaling by targeting of Ywhaz and suppresses the mesangial hypertrophy in early diabetic nephropathy. FEBS Lett 586(1):20-6 |
| abstractText | Diabetic nephropathy (DN) is a major diabetic complication. However, the initiating molecular events triggering DN are unknown. In this study we focused on microRNA-451 (miR-451), which is downregulated during early DN. We found that miR-451 negatively regulated the expression of Ywhaz through Ywhaz 3'UTR and that Ywhaz was required for the miR-451-mediated downregulation of p38 MAPK signalling. Moreover, over-expression of miR-451 inhibits glomerular mesangial cell proliferation in vitro and in vivo. These findings suggest that the growth-inhibitory effect of miR-451 may be explained in part by miR-451-induced suppression of Ywhaz and p38 MAPK signalling, providing evidence for the potential role of miR-451 in early DN. |
