| First Author | Aibara D | Year | 2013 |
| Journal | Biol Pharm Bull | Volume | 36 |
| Issue | 11 | Pages | 1766-72 |
| PubMed ID | 24189421 | Mgi Jnum | J:322235 |
| Mgi Id | MGI:6880096 | Doi | 10.1248/bpb.b13-00351 |
| Citation | Aibara D, et al. (2013) Expression of hepatic fat-specific protein 27 depends on the specific etiology of fatty liver. Biol Pharm Bull 36(11):1766-72 |
| abstractText | Fat-specific protein 27 gene (FSP27), isolated by screening for genes specifically expressed in fully differentiated mouse adipocytes, belongs to the cell death-inducing DNA fragmentation factor, alpha subunit-like effector family. FSP27 is induced in not only adipose tissue but also the liver of ob/ob mice, and it promotes the development of fatty liver. The FSP27 gene is expressed in a fatty liver-specific manner and is not detected in the normal mouse liver. FSP27 expression is directly regulated by the induction of the hepatic peroxisome proliferator-activated receptor gamma (PPARgamma) in ob/ob fatty liver. In the present study, expression of hepatic FSP27 mRNA was determined in non-genetic fatty liver models. The FSP27 gene was markedly induced in the high-fat- or methionine- and choline-deficient (MCD) diet-induced fatty liver, but it was not elevated in alcohol-induced fatty liver. Interestingly, the induction of FSP27 mRNA due to the MCD diet was independent of PPARgamma levels and completely absent in the liver from PPARgamma-null mice. These results suggest that FSP27 mRNA expression in the liver depends on the etiology of fatty liver. |
