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Publication : Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans.

First Author  Liss KHH Year  2018
Journal  J Lipid Res Volume  59
Issue  9 Pages  1630-1639
PubMed ID  29853530 Mgi Jnum  J:264623
Mgi Id  MGI:6197345 Doi  10.1194/jlr.M084947
Citation  Liss KHH, et al. (2018) Metabolic importance of adipose tissue monoacylglycerol acyltransferase 1 in mice and humans. J Lipid Res 59(9):1630-1639
abstractText  Adipocyte triglyceride storage provides a reservoir of energy that allows the organism to survive times of nutrient scarcity, but excessive adiposity has emerged as a health problem in many areas of the world. Monoacylglycerol acyltransferase (MGAT) acylates monoacylglycerol to produce diacylglycerol; the penultimate step in triglyceride synthesis. However, little is known about MGAT activity in adipocytes, which are believed to rely primarily on another pathway for triglyceride synthesis. We show that expression of the gene that encodes MGAT1 is robustly induced during adipocyte differentiation and that its expression is suppressed in fat of genetically-obese mice and metabolically-abnormal obese human subjects. Interestingly, MGAT1 expression is also reduced in physiologic contexts where lipolysis is high. Moreover, knockdown or knockout of MGAT1 in adipocytes leads to higher rates of basal adipocyte lipolysis. Collectively, these data suggest that MGAT1 activity may play a role in regulating basal adipocyte FFA retention.
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