| First Author | Hummel KP | Year | 1973 |
| Journal | Mouse News Lett | Volume | 48 |
| Pages | 34 | Mgi Jnum | J:27525 |
| Mgi Id | MGI:75014 | Citation | Hummel KP, et al. (1973) Allele test. Mouse News Lett 48:34 |
| abstractText | Full text of MNL contribution: Allele Test: We have found that diabetes (db) and adipose (ad) are alleles, contrary to Dr. D.S. Falconer's report of non-allelism (MNL 37:24). When our linkage tests showed ad to be linked to pintail (Pt) on Chromosome 4 (LG VIII) with 4 +/- 4.2% recombination, a test for allelism was indicated since Pt is about 4 units from misty (m) with which db is closely linked (1.4 +/- 0.74% recombination). Of 35 offspring from 4 matings between adipose heterozygotes and diabetes heterozygotes, 14 or 40% were of the db/db phenotype. One ad/+ male mated to 3 db/+ females produced 25 young, 11 of which were fat and a second ad/+ male mated to a db/+ female produced 3 fat offspring out of 10. These results were immediately reported to Dr. Falconer who has confirmed the allelism (see his report this issue). Because diabetes has been distributed and studied more extensively than adipose, we suggest that the priority of ad be overruled and the locus be known as diabetes (db) with the adipose allele being designated as dbad in future publications. We are offering to anyone interested the diabetes allele (dbad) which we have established on an inbred strain background (C57BL/KsJ) and which we do not plan to maintain. The strain, C57BL/KsJ-dbad +/+ m, is a "balanced stock" in which diabetes heterozygotes can be distinguished without breeding tests. We believe the diabetic syndrome to be identical to that of db and db2J on the C57BL/KsJ background. Details will be supplied on request. (Hummel, Chapman, Coleman). |
