| First Author | Lalonde R | Year | 1994 |
| Journal | Pharmacol Biochem Behav | Volume | 49 |
| Issue | 4 | Pages | 777-9 |
| PubMed ID | 7886086 | Mgi Jnum | J:22067 |
| Mgi Id | MGI:69958 | Doi | 10.1016/0091-3057(94)90222-4 |
| Citation | Lalonde R, et al. (1994) Effects of an ectodermal microceptor preparation on motor coordination in cerebellar mutant mice. Pharmacol Biochem Behav 49(4):777-9 |
| abstractText | Lurcher mutant mice, characterized by degeneration of the olivocerebellar system, and dystonia musculorum (dt) mutant mice, characterized by degeneration of spinocerebellar fibers, were treated with an ectodermal microceptor preparation (EMP), a compound containing natural substances derived from embryonic bovine ectodermal tissue, or with placebo, and evaluated in motor coordination tests. EMP-treated lurchers, but not dt mutants, were quicker to initiate movement than placebo-treated controls in the inclined beam test. No group differences were found in terms of distance travelled on the beam or in motor coordination assessed in a more challenging coat-hanger test. These results indicate that ectodermal microceptors may improve movement initiation of cerebellar-related disorders in animals, but that these effects are test and disease-specific. |
