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Publication : Universal DNA methylation age across mammalian tissues.

First Author  Lu AT Year  2023
Journal  Nat Aging Volume  3
Issue  9 Pages  1144-1166
PubMed ID  37563227 Mgi Jnum  J:349158
Mgi Id  MGI:7645971 Doi  10.1038/s43587-023-00462-6
Citation  Lu AT, et al. (2023) Universal DNA methylation age across mammalian tissues. Nat Aging 3(9):1144-1166
abstractText  Aging, often considered a result of random cellular damage, can be accurately estimated using DNA methylation profiles, the foundation of pan-tissue epigenetic clocks. Here, we demonstrate the development of universal pan-mammalian clocks, using 11,754 methylation arrays from our Mammalian Methylation Consortium, which encompass 59 tissue types across 185 mammalian species. These predictive models estimate mammalian tissue age with high accuracy (r > 0.96). Age deviations correlate with human mortality risk, mouse somatotropic axis mutations and caloric restriction. We identified specific cytosines with methylation levels that change with age across numerous species. These sites, highly enriched in polycomb repressive complex 2-binding locations, are near genes implicated in mammalian development, cancer, obesity and longevity. Our findings offer new evidence suggesting that aging is evolutionarily conserved and intertwined with developmental processes across all mammals.
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