| First Author | DiMattia GE | Year | 1997 |
| Journal | Dev Biol | Volume | 182 |
| Issue | 1 | Pages | 180-90 |
| PubMed ID | 9073460 | Mgi Jnum | J:39064 |
| Mgi Id | MGI:86445 | Doi | 10.1006/dbio.1996.8472 |
| Citation | DiMattia GE, et al. (1997) The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers. Dev Biol 182(1):180-90 |
| abstractText | The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit- 1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1. Gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1-defective Snell dwarf as a genetic background, we demonstrate that the Pit-1 gene utilizes distinct enhancers for initial gene activation and for subsequent autoregulation (required for maintenance of expression) and that Pit-1-dependent activation of the distal enhancer can be mediated in the absence of the early enhancer. These two distinct enhancers provide the basis for temporally specific regulation by discrete pituitary-specific factors, events likely to be prototypic for regulation of other classes of genes encoding transcription factors controlling terminal differentiation. (C) 1997 Academic Press. |
