| First Author | Zdanowicz MM | Year | 1995 |
| Journal | Endocrinology | Volume | 136 |
| Issue | 11 | Pages | 4880-6 |
| PubMed ID | 7588220 | Mgi Jnum | J:29761 |
| Mgi Id | MGI:77280 | Doi | 10.1210/endo.136.11.7588220 |
| Citation | Zdanowicz MM, et al. (1995) Effect of insulin-like growth factor I in murine muscular dystrophy. Endocrinology 136(11):4880-6 |
| abstractText | In muscular dystrophy there is an imbalance between muscle protein synthesis and protein degradation, resulting in net muscle catabolism and progressive muscle weakness and wasting. Both insulin and insulin-like growth factor I (IGF-I) are known to have an anabolic effect on skeletal muscle, which is believed to be enhanced in the presence of elevated concentrations of amino acids. We examined the effects of 4-week administration of recombinant human IGF-I (rhIGF-I), both alone and supplemented with a high protein diet (HPD), on muscle metabolism, morphology, and function in the 129 ReJ dystrophic mouse. rhIGF-I significantly reduced muscle protein degradation (P < 0.001), increased muscle protein content (P < 0.05), decreased fiber area variability (P < 0.01), and increased hind limb utilization (P < 0.01). Supplementation of rhIGF-I therapy with a HPD resulted in a significant increase in muscle protein synthesis (P < 0.05) in addition to a further increase in the above parameters. We conclude that rhIGF-I causes an improvement in muscle metabolism, morphology, and function in dystrophic mice, and this effect is further enhanced by the presence of a HPD. |
