| Primary Identifier | MGI:1856044 | Allele Type | Chemically induced (ENU) |
| Gene | Hbb | Inheritance Mode | Not Specified |
| Strain of Origin | (T x 101/H)F1 | Is Recombinase | false |
| Is Wild Type | false |
| description | The oxygen affinity of hemoglobin is increased in mutant mice. Because erythrocytes give up oxygen to the tissues less readily, polycythemia, with marked increases in red cell number, packed cell volume, and blood hemoglobin, results (J:13920). This murine polycythemia is homologous with hemoglobin Ranier in human (OMIM 141900, see .0232). |
| molecularNote | Polycythaemia is a mutation in Hbb-b1. Amino acid analysis of the mutant globin produced from this allele demostrated that a single substitution beta 145 Tyr to Cys occurred, and the authors proposed that mutagen induced an A-to-G transition in the tyrosine codon (TAC-to-TGC). |
