| First Author | Whitmore S | Year | 1983 |
| Journal | Mouse News Lett | Volume | 69 |
| Pages | 18 | Mgi Jnum | J:13944 |
| Mgi Id | MGI:62122 | Citation | Whitmore S, et al. (1983) Creepers. Mouse News Lett 69:18 |
| abstractText | Full text of MNL contribution: Creepers. In early 1982 a spontaneous neuromuscular mutant was found in the B10.D2 (R106) strain received from Dr. J. Forman. We are provisionally calling it "creeper" and using cpr as its symbol. It is inherited as an autosomal recessive. Homozygous females are fertile. Homozygous males are unable to breed; spermatogenesis and sperm morphology have not yet been examined. Clinically, affected mice flex both fore and rear limbs in alternating exaggerated jerks during voluntary movement. Placing response and swimming are normal. Affected mice appear flattened and rest on their bellies, and during movement frequently prop themselves with their chins. On the B10.D2 (R106) background homozygous mice can be identified between 14 and 25 days of age. In a B10.D2 (R106) X BALB/cCrAo F2, those affected can be identified between 21 and 50 days of age. After the initial time of identification, symptoms remain constant in severity with advancing age. Life span of affected mice is normal provided they live through weaning age. In litters born to B10.D2 (R106) cpr/cpr X cpr/+ parent, preweaning mortality is 47%. In R106C F2 litters, preweaning mortality is 12%. Preliminary hematoxylin and eosin of brain and spinal columns have not shown any obvious abnormality, although with luxol fast blue there are possibly differences i n myelinization between cpr/cpr and +/+ 1ittermates. Electron microscopy studies are presently under way. F2 segregants of a cross B10.D2 (R106) cpr/cpr and BALB/cCrAo have been screened for isozymes by Dr. Susan Lewis of Research Triangle Institute. Linkage with all markers except Ggc (gamma glutamyl cyclotransferase) was negative. Preliminary results indicate that the mutant is on Ch. 6. Allelism with ho (hotfoot) has not been eliminated. (S. Whitmore, J. Bresnahan [Div. Lab. An. Res]) |
