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Publication : Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis.

First Author  Heiniger HJ Year  1976
Journal  J Natl Cancer Inst Volume  56
Issue  5 Pages  1073-4
PubMed ID  186616 Mgi Jnum  J:5726
Mgi Id  MGI:54203 Doi  10.1093/jnci/56.5.1073
Citation  Heiniger HJ, et al. (1976) Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis. J Natl Cancer Inst 56(5):1073-4
abstractText  Leukemia-prone hairless (HRS/J; hr/hr) mice had significantly higher leukemia virus titers than did the leukemia-resistant nonmutants (hr/ + and +/+). This difference was ascribed to the allelic substitution at a single gene locus; at 6 months of age it averaged 13-fold, immediately preceding the large divergence in leukemia incidence between the mutant and nonmutant mice.
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