| First Author | Reske-Kunz AB | Year | 1979 |
| Journal | J Exp Med | Volume | 149 |
| Issue | 1 | Pages | 228-33 |
| PubMed ID | 310859 | Mgi Jnum | J:6087 |
| Mgi Id | MGI:54564 | Doi | 10.1084/jem.149.1.228 |
| Citation | Reske-Kunz AB, et al. (1979) Disproportion in T-cell subpopulations in immunodeficient mutant hr/hr mice. J Exp Med 149(1):228-33 |
| abstractText | Mice of the HRS strain, which carry the mutant gene hr, were examined for abnormalities in representation of the three T-cell sets Ly1, Ly23, and Ly123 in the spleen. The salient feature of hr/hr mice, which are immunologically deficient, in comparison with +/hr segregants, was a gross disproportion in numbers of cells belonging to the Ly1 and Ly123 sets, at the age of 3--3.5 mo. At this age, Ly123 cells of hr/hr spleen outnumbered Ly1 cells by 2:1, whereas in +/hr spleens Ly123 cells were outnumbered by approximately 1:2. Cells from pooled lymph nodes of hr/hr mice did not show a correspondingly gross disporprotion of Ly1 and Ly123 cells. Total counts of splenic T cells, and of B cells, were not significantly different in hr/hr and +/hr mice. |
