| First Author | Mikoshiba K | Year | 1985 |
| Journal | J Neurochem | Volume | 44 |
| Issue | 3 | Pages | 686-91 |
| PubMed ID | 2579194 | Mgi Jnum | J:7747 |
| Mgi Id | MGI:56216 | Doi | 10.1111/j.1471-4159.1985.tb12869.x |
| Citation | Mikoshiba K, et al. (1985) Immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase and myelin basic protein in the central nervous system of the jimpy and the normal mouse. J Neurochem 44(3):686-91 |
| abstractText | We describe the immunohistochemical localization of 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) and myelin basic protein (MBP) in CNS of the jimpy mutant mouse which is characterized by dys- and demyelination. In controls, the CNPase and MBP were localized exclusively in white matter in the CNS. The jimpy mutant mice were severely affected: A very weak reaction was observed in the white matter. Very few CNPase- and MBP-positive myelin sheaths were observed, and some degradation products were also observed after reaction with antisera against both CNPase and MBP. The immunohistochemical reaction in the jimpy mice showed a similar localization in both CNPase and MBP. |
