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Publication : The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice.

First Author  Moriguchi A Year  1987
Journal  Gene Volume  55
Issue  2-3 Pages  333-7
PubMed ID  2444499 Mgi Jnum  J:20094
Mgi Id  MGI:68207 Doi  10.1016/0378-1119(87)90293-9
Citation  Moriguchi A, et al. (1987) The fifth exon of the myelin proteolipid protein-coding gene is not utilized in the brain of jimpy mutant mice. Gene 55(2-3):333-7
abstractText  The jimpy mouse, an X-linked recessive dysmyelinating and demyelinating mutant, has been shown to contain abnormal myelin proteolipid protein (PLP) mRNA. To understand the molecular basis of the mutation, we analyzed the structure of PLP mRNA by an RNase-mapping procedure, using the probes specific to each exon of the mouse PLP gene. We found that the fifth exon of the PLP gene is not utilized in the jimpy.
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