| First Author | Hou J | Year | 2014 |
| Journal | Cancer Cell | Volume | 25 |
| Issue | 1 | Pages | 49-63 |
| PubMed ID | 24360797 | Mgi Jnum | J:208171 |
| Mgi Id | MGI:5561193 | Doi | 10.1016/j.ccr.2013.11.011 |
| Citation | Hou J, et al. (2014) Hepatic RIG-I predicts survival and interferon-alpha therapeutic response in hepatocellular carcinoma. Cancer Cell 25(1):49-63 |
| abstractText | In hepatocellular carcinoma (HCC), biomarkers for prediction of prognosis and response to immunotherapy such as interferon-alpha (IFN-alpha) would be very useful in the clinic. We found that expression of retinoic acid-inducible gene-I (RIG-I), an IFN-stimulated gene, was significantly downregulated in human HCC tissues. Patients with low RIG-I expression had shorter survival and poorer response to IFN-alpha therapy, suggesting that RIG-I is a useful prognosis and IFN-alpha response predictor for HCC patients. Mechanistically, RIG-I enhances IFN-alpha response by amplifying IFN-alpha effector signaling via strengthening STAT1 activation. Furthermore, we found that RIG-I deficiency promotes HCC carcinogenesis and that hepatic RIG-I expression is lower in men than in women. RIG-I may therefore be a tumor suppressor in HCC and contribute to HCC gender disparity. |
