| First Author | Beechey CV | Year | 1986 |
| Journal | Mouse News Lett | Volume | 74 |
| Pages | 92 | Mgi Jnum | J:14074 |
| Mgi Id | MGI:62251 | Citation | Beechey CV, et al. (1986) Banded - a new W allele. Mouse News Lett 74:92 |
| abstractText | Full text of MNL contribution: b) Banded - a new W-allele. W<26H> resembles sash (W<Sh>) as follows:- (1) heterozygotes have a broad band of depigmentation in the trunk region, (ii) homozygotes are black-eyed white apart from a variable but slight amount of pigmentation on the head, especially ears, and occasionally the tail; the adjacent rump region may also have some traces of pigmentation in (W<26HW26H>, (iii) homozygotes are viable and fertile in both sexes with no obvious signs of anaemia (Lyon and Glenister, Genet. Res. 39:315-322, 1982; Beechey and Searle, MNL 68:70, 1983). However, crosses between W<Sh> and W<26H> gave black-eyed whites with more pigmentation on the head than either homozygote. Haematological studies on W<26H> have revealed further similarities between the two mutants, but differences emerged when the factor of radiation was added. Neither W<26H> nor W<sh> are demonstrably anaemic or macrocytic in the heterozygote but W<26H>/W<26H> may be marginally anaemic, although mean RBC count (8.9 x 10<9>ml<-l>) and mean cell volume (50 um<3>) are not significantly different from W<sh> homozygotes. However, while W<sh>/+ was not distinguishable from +/+ in haematological response to radiation stress, W<26H>/+ responded to 5 Gy (500 rad) X-rays with significantly greater anaemia than +/+ at 15 days. This effect was similar to that of the same radiation dose on W<sh> homozygotes, while radiation effects on W<26H> homozygotes were more severe, with delayed recovery of red cell counts evident at 6 Gy. Thus it appears that two doses of the W<sh> allele, but only one dose of W<26H>, are needed to demonstrate an increased effect of irradiation. These findings suggest that W<26H> is not identical with W<Sh>. W<26H> also differs in its effects from all the ten new W mutations described by Geissler et al. (1981. Genetics 97:337-361). Therefore we have given it the name, banded, with symbol W<bd>. (Beechey, Loutit, Searle) |
