| First Author | Siggers P | Year | 2002 |
| Journal | Mech Dev | Volume | 111 |
| Issue | 1-2 | Pages | 159-62 |
| PubMed ID | 11804789 | Mgi Jnum | J:74486 |
| Mgi Id | MGI:2158540 | Doi | 10.1016/s0925-4773(01)00602-5 |
| Citation | Siggers P, et al. (2002) Sexually dimorphic expression of Gata-2 during mouse gonad development. Mech Dev 111(1-2):159-62 |
| abstractText | We report that Gata-2 is expressed in a sexually dimorphic fashion during mouse gonadogenesis. Gata-2 transcripts accumulate rapidly in the fetal ovary from 11.5 days post coitum (dpc) onwards, but are not detected in the fetal testis throughout the period studied (10.5-15.5 dpc). Ovarian expression of Gata-2 ceases by 15.5 dpc. Examination of ovaries from embryos homozygous for the extreme allele of c-kit(W(e)) (Nature, 335, 88; Cell, 55, 185) demonstrates that ovarian Gata-2 expression is dependent upon the presence of germ cells. Comparative in situ hybridisation using the germ cell marker Oct4 (EMBO J., 8, 2543) indicates that Gata-2 transcripts are restricted to the germ cell lineage at 13.5 dpc. |
