| First Author | Kim HS | Year | 2019 |
| Journal | Sci Adv | Volume | 5 |
| Issue | 7 | Pages | eaav8152 |
| PubMed ID | 31328158 | Mgi Jnum | J:288088 |
| Mgi Id | MGI:6415889 | Doi | 10.1126/sciadv.aav8152 |
| Citation | Kim HS, et al. (2019) The regulatory B cell-mediated peripheral tolerance maintained by mast cell IL-5 suppresses oxazolone-induced contact hypersensitivity. Sci Adv 5(7):eaav8152 |
| abstractText | The function of regulatory immune cells in peripheral tissues is crucial to the onset and severity of various diseases. Interleukin-10 (IL-10)-producing regulatory B (IL-10(+) Breg) cells are known to suppress various inflammatory diseases. However, evidence for the mechanism by which IL-10(+) Breg cells are generated and maintained is still very limited. Here, we found that IL-10(+) Breg cells suppress the activation of IL-13-producing type 2 innate lymphoid cells (IL-13(+) ILC2s) in an IL-10-dependent manner in mice with oxazolone-induced severe contact hypersensitivity (CHS). Mast cell (MC) IL-5 was important for maintaining the population of IL-10(+) Breg cells in peripheral lymphoid tissues. Overall, these results uncover a previously unknown mechanism of MCs as a type of immunoregulatory cell and elucidate the cross-talk among MCs, IL-10(+) Breg cells, and IL-13(+) ILC2s in CHS. |
