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Publication : Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths.

First Author  Ohnmacht C Year  2010
Journal  Immunity Volume  33
Issue  3 Pages  364-74
PubMed ID  20817571 Mgi Jnum  J:164432
Mgi Id  MGI:4833891 Doi  10.1016/j.immuni.2010.08.011
Citation  Ohnmacht C, et al. (2010) Basophils orchestrate chronic allergic dermatitis and protective immunity against helminths. Immunity 33(3):364-74
abstractText  Basophils are associated with T helper 2 (Th2) cell-polarized immune responses such as allergic disorders or helminth infections. To directly address the role of basophils for type 2 immunity, we generated transgenic mice with constitutive and selective deletion of basophils. Differentiation and accumulation of Th2 cells, induction of eosinophilia, and increase in serum IgE or IgG1 induced by allergens or by infection with the helminth Nippostrongylus brasiliensis appeared to be basophil independent. Further, basophils were not required for passive IgE- or IgG1-mediated systemic anaphylaxis. However, basophils were essential for IgE-meditated chronic allergic dermatitis and for protection against secondary infection with N. brasiliensis. These results demonstrate that basophils play an important role for protective immunity against helminths and orchestrate chronic allergic inflammation, whereas primary Th2 cell responses can operate efficiently in the absence of this cell type.
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