| First Author | de Vries VC | Year | 2011 |
| Journal | Immunity | Volume | 35 |
| Issue | 4 | Pages | 550-61 |
| PubMed ID | 22035846 | Mgi Jnum | J:177851 |
| Mgi Id | MGI:5296402 | Doi | 10.1016/j.immuni.2011.09.012 |
| Citation | de Vries VC, et al. (2011) Mast cells condition dendritic cells to mediate allograft tolerance. Immunity 35(4):550-61 |
| abstractText | Peripheral tolerance orchestrated by regulatory T cells, dendritic cells (DCs), and mast cells (MCs) has been studied in several models including skin allograft tolerance. We now define a role for MCs in controlling DC behavior ("conditioning") to facilitate tolerance. Under tolerant conditions, we show that MCs mediated a marked increase in tumor necrosis factor (TNFalpha)-dependent accumulation of graft-derived DCs in the dLN compared to nontolerant conditions. This increase of DCs in the dLN is due to the local production of granulocyte macrophage colony-stimulating factor (GM-CSF) by MCs that induces a survival advantage of graft-derived DCs. DCs that migrated to the dLN from the tolerant allograft were tolerogenic; i.e., they dominantly suppress T cell responses and control regional immunity. This study underscores the importance of MCs in conditioning DCs to mediate peripheral tolerance and shows a functional impact of peripherally produced TNFalpha and GM-CSF on the migration and function of tolerogenic DCs. |
