| First Author | Toyoshima S | Year | 2017 |
| Journal | Int Immunol | Volume | 29 |
| Issue | 1 | Pages | 31-45 |
| PubMed ID | 28177443 | Mgi Jnum | J:249858 |
| Mgi Id | MGI:5923268 | Doi | 10.1093/intimm/dxx005 |
| Citation | Toyoshima S, et al. (2017) The spleen is the site where mast cells are induced in the development of food allergy. Int Immunol 29(1):31-45 |
| abstractText | It has been reported that splenic immune responses play pivotal roles in the development of allergic diseases; however, the precise role of the spleen remains unclear. Herein, we demonstrated a novel role of the spleen in the pathogenesis of food allergy (FA). We found that mast cells (MCs) developed from progenitor cells present in spleen during an antigen-specific T-cell response in vitro. In a Th2 response-mediated FA model, significant expansion of MCs was also observed in spleen. The incidence of allergic diarrhea was profoundly reduced in splenectomized mice, whereas adoptive transfer of in vitro-induced splenic MCs into these mice restored allergic symptoms, suggesting that the splenic MCs functioned as the pathogenic cells in the development of FA. The in vitro-generated MCs required not only IL-3 but also IFN-gamma, and treatment of FA-induced mice with anti-IFN-gamma antibody suppressed expansion of MCs in spleen as well as diarrhea development, highlighting that IFN-gamma in the spleen orchestrated the development of FA, which was followed by a Th2 response in the local lesion. Overall, we propose that the role of the spleen in the development of FA is to provide a unique site where antigen-specific T cells induce development of pathogenic MCs. |
