| First Author | Seehus CR | Year | 2017 |
| Journal | Nat Commun | Volume | 8 |
| Issue | 1 | Pages | 1900 |
| PubMed ID | 29196657 | Mgi Jnum | J:258391 |
| Mgi Id | MGI:6112081 | Doi | 10.1038/s41467-017-02023-z |
| Citation | Seehus CR, et al. (2017) Alternative activation generates IL-10 producing type 2 innate lymphoid cells. Nat Commun 8(1):1900 |
| abstractText | Type 2 innate lymphoid cells (ILC2) share cytokine and transcription factor expression with CD4(+) Th2 cells, but functional diversity of the ILC2 lineage has yet to be fully explored. Here, we show induction of a molecularly distinct subset of activated lung ILC2, termed ILC210. These cells produce IL-10 and downregulate some pro-inflammatory genes. Signals that generate ILC210 are distinct from those that induce IL-13 production, and gene expression data indicate that an alternative activation pathway leads to the generation of ILC210. In vivo, IL-2 enhances ILC210 generation and is associated with decreased eosinophil recruitment to the lung. Unlike most activated ILC2, the ILC210 population contracts after cessation of stimulation in vivo, with maintenance of a subset that can be recalled by restimulation, analogous to T-cell effector cell and memory cell generation. These data demonstrate the generation of a previously unappreciated IL-10 producing ILC2 effector cell population. |
