| First Author | Lee DM | Year | 2002 |
| Journal | Science | Volume | 297 |
| Issue | 5587 | Pages | 1689-92 |
| PubMed ID | 12215644 | Mgi Jnum | J:78906 |
| Mgi Id | MGI:2386469 | Doi | 10.1126/science.1073176 |
| Citation | Lee DM, et al. (2002) Mast cells: a cellular link between autoantibodies and inflammatory arthritis. Science 297(5587):1689-92 |
| abstractText | Previous studies have revealed that autoantibodies, complement components, and Fc receptors each participate in the pathogenesis of erosive arthritis in K/BxN mice. However, it is not known which cellular populations are responsive to these inflammatory signals. We find that two strains of mice deficient in mast cells, W/Wv and Sl/Sld, were resistant to development of joint inflammation and that susceptibility was restored in the W/Wv strain by mast cell engraftment. Thus, mast cells may function as a cellular link between autoantibodies, soluble mediators, and other effector populations in inflammatory arthritis. |
