| First Author | Ierna MX | Year | 2008 |
| Journal | Mucosal Immunol | Volume | 1 |
| Issue | 2 | Pages | 147-55 |
| PubMed ID | 19079172 | Mgi Jnum | J:191926 |
| Mgi Id | MGI:5463564 | Doi | 10.1038/mi.2007.16 |
| Citation | Ierna MX, et al. (2008) Mast cell production of IL-4 and TNF may be required for protective and pathological responses in gastrointestinal helminth infection. Mucosal Immunol 1(2):147-55 |
| abstractText | Expulsion of the gastrointestinal nematode Trichinella spiralis is associated with Th2 responses and intestinal inflammation, which correlate with a marked mast cell (MC) response. To address the role of MC-derived cytokines in the induction of protective responses, WBB6F1-KitW/KitW-v (W/W(v)) mice were reconstituted with wild-type, tumor necrosis factor (TNF)-alpha(-/-), or interleukin (IL)-4(-/-) bone marrow (BM) prior to infection with T. spiralis. W/W(v) mice reconstituted with TNF-alpha(-/-) or IL-4(-/-) BM expelled the parasite less efficiently and showed diminished enteropathy, whereas protective responses were normal in W/W(v) mice reconstituted with wild-type BM and were accompanied by intestinal pathology. MC responses were reduced in W/W(v) mice reconstituted with IL-4(-/-) BM and to a lesser extent when reconstituted with TNF-alpha(-/-). These results suggest that MC-derived IL-4 and TNF may regulate the induction of protective Th2 responses and intestinal inflammation associated with the expulsion of T. spiralis. Significantly, these studies suggest a role for MC-derived cytokines as autocrine growth factors. |
