| First Author | Edelson BT | Year | 2004 |
| Journal | Blood | Volume | 103 |
| Issue | 6 | Pages | 2214-20 |
| PubMed ID | 14645004 | Mgi Jnum | J:88567 |
| Mgi Id | MGI:3034130 | Doi | 10.1182/blood-2003-08-2978 |
| Citation | Edelson BT, et al. (2004) Mast cell-mediated inflammatory responses require the alpha 2 beta 1 integrin. Blood 103(6):2214-20 |
| abstractText | Although the alpha 2 beta 1 integrin is widely expressed and has been extensively studied, it has not been previously implicated in mast cell biology. We observed that alpha 2 integrin subunit-deficient mice exhibited markedly diminished neutrophil and interleukin-6 responses during Listeria monocytogenes- and zymosan-induced peritonitis. Since exudative neutrophils of wild-type mice expressed little alpha 2 beta 1 integrin, it seemed unlikely that this integrin mediated neutrophil migration directly. Here, we demonstrate constitutive alpha 2 beta 1 integrin expression on peritoneal mast cells. Although alpha 2-null mice contain normal numbers of peritoneal mast cells, these alpha 2-null cells do not support in vivo mast cell-dependent inflammatory responses. We conclude that alpha 2 beta 1 integrin provides a costimulatory function required for mast cell activation and cytokine production in response to infection. |
