| First Author | Matsui K | Year | 1993 |
| Journal | Life Sci | Volume | 53 |
| Issue | 4 | Pages | 333-40 |
| PubMed ID | 8100981 | Mgi Jnum | J:14712 |
| Mgi Id | MGI:62875 | Doi | 10.1016/0024-3205(93)90752-o |
| Citation | Matsui K, et al. (1993) Levels of somatostatin and cholecystokinin in the brain of ataxic mutant mice. Life Sci 53(4):333-40 |
| abstractText | Changes in immunoreactive somatostatin (SOM) and cholecystokinin (CCK-8) levels in the cerebellum and cerebrum were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and Purkinje cell degeneration (PCD) mice. The cerebellar pathology in each of these types differs. The concentration of both SOM and CCK-8 (ng/mg weight) was significantly higher in the cerebellum and the cerebrum of the three types of ataxic mutant mice than in these regions in the respective controls. SOM and CCK-8 content (ng/organ) was significantly higher in PCD and RMN than in controls but this was not in the weaver mice. The possible involvement of both peptides in manifestations of ataxia is discussed. |
