| First Author | Ohba T | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 381 |
| Issue | 1 | Pages | 27-32 |
| PubMed ID | 19351589 | Mgi Jnum | J:147431 |
| Mgi Id | MGI:3840723 | Doi | 10.1016/j.bbrc.2009.01.184 |
| Citation | Ohba T, et al. (2009) Modified autonomic regulation in mice with a P/Q-type calcium channel mutation. Biochem Biophys Res Commun 381(1):27-32 |
| abstractText | Recent genetic analyses revealed an important association between P/Q-type channels and hereditary neurological disorders. The alpha1 subunit of P/Q-type channels is coded by a single CaV2.1 gene. Since calcium entry via neuronal calcium channels is essential for neurotransmission, P/Q-type channels may play an important role in cardiac autonomic neurotransmission. To elucidate the physiological importance of P/Q-type channels in autonomic nerve control, we used rolling Nagoya (tg(rol)) mice, which have a mutation in the CaV2.1 gene and decreased P/Q-type channel currents with reduced voltage sensitivity. The tg(rol) mice demonstrated unmodified expression of other calcium channel subunits. Electrocardiogram and echocardiographic analyses revealed decreased heart rate. Furthermore, omega-agatoxin IVA, a P/Q-type channel inhibitor, decreased heart rate and ejection fraction only in wild-type mice, thus suggesting a significant involvement of P/Q-type channels in chronotropic regulation. Atrium contraction analyses revealed a minor but significant role for P/Q-type channels in sympathetic and parasympathetic nerve regulation. |
