| First Author | Takahashi E | Year | 2010 |
| Journal | Behav Brain Res | Volume | 213 |
| Issue | 1 | Pages | 121-5 |
| PubMed ID | 20420856 | Mgi Jnum | J:160364 |
| Mgi Id | MGI:4454348 | Doi | 10.1016/j.bbr.2010.04.030 |
| Citation | Takahashi E, et al. (2010) Impairment of spatial short-term memory following acute administration of the NMDA receptor antagonist in heterozygous rolling Nagoya mice carrying the Ca V 2.1 alpha1 mutation. Behav Brain Res 213(1):121-5 |
| abstractText | Heterozygous rolling Nagoya (rol/+) mice carrying Ca(V)2.1 alpha(1) mutation demonstrated normal behavior in Y maze test. Similar spontaneous alternation patterns were noted in wild-type and rol/+ mice injected with N-methyl-D-aspartate (NMDA; 0-50mg/kg, sc). Systemic injection of NMDA receptor blocker (MK-801; 0.05 mg/kg, ip) or intrahippocampal injection of MK-801 (0.5 microg/side), which had no effect in wild-type controls, decreased spatial cognition in rol/+ mice. These results indicate that Ca(V)2.1 alpha(1) mutation probably through decrease in Ca(2+) influx lowers the threshold for learning impairment. The combination subthreshold pharmacological and genetic approach is useful to study functional pathways in neuronal circuits. |
