| First Author | Murakami M | Year | 2015 |
| Journal | Biochem Biophys Res Commun | Volume | 461 |
| Issue | 2 | Pages | 200-5 |
| PubMed ID | 25892515 | Mgi Jnum | J:228375 |
| Mgi Id | MGI:5706875 | Doi | 10.1016/j.bbrc.2015.03.112 |
| Citation | Murakami M, et al. (2015) Modified autonomic regulation in mice mutated in the beta4 subunit of the lh/lh calcium channel. Biochem Biophys Res Commun 461(2):200-5 |
| abstractText | Genetic analyses have revealed an important association between P/Q-type calcium channel activities and hereditary neurological disorders. The P/Q-type channels are composed principally of heterologous multimeric subunits including CaV2.1 and CaVbeta4. Of these, the beta4 subunit is thought to play a significant role in channel physiology, because a mouse line mutant in that subunit (the lethargic mouse: lh) exhibits a severe ataxic phenotype. The aim of the present study was to elucidate the physiological importance of the beta4 subunit. ECG analysis showed that the T wave was high in 8-week-old lh mutants; this may be associated with hyperkalemia. Upon pharmacological ECG analysis, 2-3-week-old lh mutants exhibited reduced responses to a beta-blocker and a muscarinic receptor antagonist. Analysis of heart rate variability revealed that the R-R interval was unstable in lh mutants and that both the low- and high-frequency components had increased in extent, indicating that the tonus of both the sympathetic and parasympathetic nervous systems was modified. Thus, our present study revealed that the beta4 subunit played a significant role in regulation of sympathetic and parasympathetic nerve activities. |
