| First Author | Matsui K | Year | 1988 |
| Journal | Jikken Dobutsu | Volume | 37 |
| Issue | 3 | Pages | 263-8 |
| PubMed ID | 2901364 | Mgi Jnum | J:28478 |
| Mgi Id | MGI:76087 | Doi | 10.1538/expanim1978.37.3_263 |
| Citation | Matsui K, et al. (1988) [Elevated immunoreactive-somatostatin levels in the brain of ataxic mutant mice]. Jikken Dobutsu 37(3):263-8 |
| abstractText | Immunoreactive-somatostatin (IR-SRIF) levels were investigated in the brain of 4 types of ataxic mice (Rolling Mouse Nagoya, Weaver, PCD, Staggerer) with different cerebellar pathologies. IR-SRIF concentrations (ng/mg) were found to be significantly elevated in both cerebellum and cerebrum of all ataxic mutant mice, IR-SRIF (ng/organ) was found to be increased in the cerebellum and cerebrum in Rolling Mouse Nagoya and PCD compared with control mice. The gel-filtration profile (Sephadex G-50) in the cerebellar extracts of Rolling Mouse Nagoya proved to be identical to that of control mice. Three peaks of IR-SRIF were found to be uniformly elevated in Rolling Mouse Nagoya, with the highest peak coinciding with authentic somatostatin-14. The present results suggest that elevated levels of IR-SRIF in the brain may play a role in the mechanism underlying the manifestation of ataxia in ataxic mutant mice, especially in Rolling Mouse Nagoya and PCD. |
