| First Author | Boiron-Sargueil F | Year | 1995 |
| Journal | Neurosci Lett | Volume | 186 |
| Issue | 1 | Pages | 21-4 |
| PubMed ID | 7783943 | Mgi Jnum | J:24439 |
| Mgi Id | MGI:72137 | Doi | 10.1016/0304-3940(95)11272-x |
| Citation | Boiron-Sargueil F, et al. (1995) Cerebroside formation in the peripheral nervous system of normal and Trembler mice. Neurosci Lett 186(1):21-4 |
| abstractText | The formation of cerebrosides by the galactosylation of ceramides was investigated in a microsomal fraction prepared from sciatic nerves of normal and Trembler mice. In the control, cerebroside synthesis is observed in the presence of uridine-diphosphate-galactose both from endogenously synthesized [1-14C]stearoyl-sphingosine (C18-ceramide), and from [1-14C]lignoceroyl-sphingosine (C24-ceramide). Cerebroside formation is also demonstrated by studying the galactosylation of exogenous ceramides with UDP[1-14C]-galactose. In the mutant, only trace amounts of labeled cerebrosides are formed from labeled stearoyl-sphingosine, whereas with lignoceroyl-sphingosine, no cerebroside synthesis is detected under conditions allowing their formation in the control. However, a higher rate of synthesis of short acyl chain-glucosyl ceramides is observed in the Trembler samples. |
