| First Author | Kosaras B | Year | 1992 |
| Journal | Mouse Genome | Volume | 90 |
| Issue | 3 | Pages | 421 |
| Mgi Jnum | J:2589 | Mgi Id | MGI:51111 |
| Citation | Kosaras B, et al. (1992) Vitiligo (mivit) linkage and retinal abnormalities. Mouse Genome 90(3):421 |
| abstractText | Full text of Mouse Genome contribution: Research News: 2. Vitiligo (mi-vit) linkage and retinal abnormalities: Complementation was not observed between vitiligo and Miwh (chr 6). (4, 5). This, together with an observed linkage of vitiligo to lurcher (chr 6) with a recombination frequency of 13.5 +/- 2.9% (estimated distance between LC and the mi locus is 12.7 +/- 2.5 cM) support the hypothesis that vitiligo is either allelic with or very close to the mi locus. On the strength of these data we recommend changing the symbol for vitiligo to mivit. We have also observed that, in addition to a progressive retinal photoreceptor degeneration in adulthood, the retinal pigment epithelium (PE) of vitiligo homozygotes is abnormal in several respects prior to the onset of photoreceptor degeneration: abnormal cell layering at embryonic stages, distorted cell-cycle kinetics in the first week postnatally and a reduction in the number of phagosomes in each PE cell, compared to controls, at postnatal days 23 and 36. |
