| First Author | Starcher B | Year | 1978 |
| Journal | J Nutr | Volume | 108 |
| Issue | 8 | Pages | 1229-33 |
| PubMed ID | 27591 | Mgi Jnum | J:6013 |
| Mgi Id | MGI:54490 | Doi | 10.1093/jn/108.8.1229 |
| Citation | Starcher B, et al. (1978) Abnormal cellular copper metabolism in the blotchy mouse. J Nutr 108(8):1229-33 |
| abstractText | Defective copper metabolism was demonstrated in male mice bearing the blotchy (Moblo/y) allele at the mottled locus on the X-chromosome. Copper absorption from the gut was only 64% of that found in normal mice and hepatic copper levels were only 56% of the controls. Ceruloplasmin and heart cytochrome c oxidase activities were normal, yet lysyl oxidase activity from cultured fibroblasts was only 45% of control levels. Copper accumulated in fibroblasts cultured from these mutants to values that were five times normal. The accumulation of copper in the fibroblasts was associated with a protein of approximately 12,000 molecular weight. |
