| First Author | Falconer DS | Year | 1972 |
| Journal | Mouse News Lett | Volume | 47 |
| Pages | 28 | Mgi Jnum | J:13531 |
| Mgi Id | MGI:61718 | Citation | Falconer DS, et al. (1972) Harlequin and brindled - linkage, and difference between coupling and repulsion phenotypes. Mouse News Lett 47:28 |
| abstractText | Full text of MNL contribution: Harlequin and brindled - linkage and difference between coupling and repulsion phenotypes. The sex linked gene harlequin, Hq, (MNL 45: 35), kindly sent to us by Dr. B.R. Berber, produces almost complete baldness in males and homozygous females, and a patchy baldness in heterozygous females. The bald areas in heterozygous females are very much less than 50% of the total and are not always easy to see. Repulsion linkage tests with brindled (Br = Mobr) give the following preliminary results. Recombination frequency in female progeny, 14 +/- 4%; in male progeny, 30 +/- 4%. Coupling tests should show if the discrepancy, which is highly significant, is due to misclassification or viability interactions. Three point tests from Br Ta +/+ + Hq have given two + Ta + males, which point to the order being Br-Ta-Hq, but this is not yet conclusive. Coupling and repulsion heterozygotes of Br and Hq are strikingly different in appearance. In coupling there are almost no brindled areas; in repulsion there are brindled areas and areas of normal pigmentation, in proportions not very different from the normal Br/+ phenotype. This description refers only to the overall appearance and may have to be revised after closer study. Further comment would be premature. (Falconer and Isaacson). |
