| First Author | Horai R | Year | 2004 |
| Journal | J Clin Invest | Volume | 114 |
| Issue | 11 | Pages | 1603-11 |
| PubMed ID | 15578092 | Mgi Jnum | J:94429 |
| Mgi Id | MGI:3512735 | Doi | 10.1172/JCI20742 |
| Citation | Horai R, et al. (2004) TNF-alpha is crucial for the development of autoimmune arthritis in IL-1 receptor antagonist-deficient mice. J Clin Invest 114(11):1603-11 |
| abstractText | IL-1 receptor antagonist-deficient (IL-1Ra(-/-)) mice spontaneously develop autoimmune arthritis. We demonstrate here that T cells are required for the induction of arthritis; T cell-deficient IL-1Ra(-/-) mice did not develop arthritis, and transfer of IL-1Ra(-/-) T cells induced arthritis in nu/nu mice. Development of arthritis was also markedly suppressed by TNF-alpha deficiency. We found that TNF-alpha induced OX40 expression on T cells and blocking the interaction between either CD40 and its ligand or OX40 and its ligand suppressed development of arthritis. These findings suggest that IL-1 receptor antagonist deficiency in T cells disrupts homeostasis of the immune system and that TNF-alpha plays an important role in activating T cells through induction of OX40. |
