| First Author | Taieb J | Year | 2006 |
| Journal | Nat Med | Volume | 12 |
| Issue | 2 | Pages | 214-9 |
| PubMed ID | 16444265 | Mgi Jnum | J:105774 |
| Mgi Id | MGI:3616498 | Doi | 10.1038/nm1356 |
| Citation | Taieb J, et al. (2006) A novel dendritic cell subset involved in tumor immunosurveillance. Nat Med 12(2):214-9 |
| abstractText | The interferon (IFN)-gamma-induced TRAIL effector mechanism is a vital component of cancer immunosurveillance by natural killer (NK) cells in mice. Here we show that the main source of IFN-gamma is not the conventional NK cell but a subset of B220(+)Ly6C(-) dendritic cells, which are atypical insofar as they express NK cell-surface molecules. Upon contact with a variety of tumor cells that are poorly recognized by NK cells, B220(+)NK1.1(+) dendritic cells secrete high levels of IFN-gamma and mediate TRAIL-dependent lysis of tumor cells. Adoptive transfer of these IFN-producing killer dendritic cells (IKDCs) into tumor-bearing Rag2(-/-)Il2rg(-/-) mice prevented tumor outgrowth, whereas transfer of conventional NK cells did not. In conclusion, we identified IKDCs as pivotal sensors and effectors of the innate antitumor immune response. |
