| First Author | Takahama Y | Year | 1992 |
| Journal | Science | Volume | 258 |
| Issue | 5082 | Pages | 653-6 |
| PubMed ID | 1357752 | Mgi Jnum | J:127343 |
| Mgi Id | MGI:3763592 | Doi | 10.1126/science.1357752 |
| Citation | Takahama Y, et al. (1992) Negative selection of precursor thymocytes before their differentiation into CD4+CD8+ cells. Science 258(5082):653-6 |
| abstractText | Thymic selection of the developing T cell repertoire is thought to occur at the CD4+CD8+ stage of differentiation and to be determined by the specificity of the T cell receptors (TCRs) that CD4+CD8+ thymocytes express. However, TCR signals can inhibit the differentiation of precursor thymocytes into CD4+CD8+ cells, which suggests that selection might occur earlier than thought. Indeed, in a negatively selecting male thymus, CD4-CD8lo precursor thymocytes that express a transgenic TCR to male antigen are developmentally arrested as a consequence of antigen encounter and fail to become CD4+CD8+. Thus, negative selection can occur before the CD4+CD8+ stage of differentiation. |
