| First Author | Karras P | Year | 2019 |
| Journal | Cancer Cell | Volume | 35 |
| Issue | 1 | Pages | 46-63.e10 |
| PubMed ID | 30581152 | Mgi Jnum | J:270032 |
| Mgi Id | MGI:6274842 | Doi | 10.1016/j.ccell.2018.11.008 |
| Citation | Karras P, et al. (2019) p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell 35(1):46-63.e10 |
| abstractText | Modulators of mRNA stability are not well understood in melanoma, an aggressive tumor with complex changes in the transcriptome. Here we report the ability of p62/SQSTM1 to extend mRNA half-life of a spectrum of pro-metastatic factors. These include FERMT2 and other transcripts with no previous links to melanoma. Transcriptomic, proteomic, and interactomic analyses, combined with validation in clinical biopsies and mouse models, identified a selected set of RNA-binding proteins (RBPs) recruited by p62, with IGF2BP1 as a key partner. This p62-RBP interaction distinguishes melanoma from other tumors where p62 controls autophagy or oxidative stress. The relevance of these data is emphasized by follow-up analyses of patient prognosis revealing p62 and FERMT2 as adverse determinants of disease-free survival. |
