| First Author | Gao Y | Year | 2007 |
| Journal | J Clin Invest | Volume | 117 |
| Issue | 1 | Pages | 122-32 |
| PubMed ID | 17173138 | Mgi Jnum | J:117462 |
| Mgi Id | MGI:3696534 | Doi | 10.1172/JCI30074 |
| Citation | Gao Y, et al. (2007) IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation. J Clin Invest 117(1):122-32 |
| abstractText | T cell-produced cytokines play a pivotal role in the bone loss caused by inflammation, infection, and estrogen deficiency. IFN-gamma is a major product of activated T helper cells that can function as a pro- or antiresorptive cytokine, but the reason why IFN-gamma has variable effects in bone is unknown. Here we show that IFN-gamma blunts osteoclast formation through direct targeting of osteoclast precursors but indirectly stimulates osteoclast formation and promotes bone resorption by stimulating antigen-dependent T cell activation and T cell secretion of the osteoclastogenic factors RANKL and TNF-alpha. Analysis of the in vivo effects of IFN-gamma in 3 mouse models of bone loss - ovariectomy, LPS injection, and inflammation via silencing of TGF-beta signaling in T cells |
