| First Author | McCoy KD | Year | 2006 |
| Journal | Immunity | Volume | 24 |
| Issue | 3 | Pages | 329-39 |
| PubMed ID | 16546101 | Mgi Jnum | J:113324 |
| Mgi Id | MGI:3665392 | Doi | 10.1016/j.immuni.2006.01.013 |
| Citation | McCoy KD, et al. (2006) Natural IgE production in the absence of MHC Class II cognate help. Immunity 24(3):329-39 |
| abstractText | IgE induction by parasites and allergens is antigen driven and cognate T cell help dependent. We demonstrate that spontaneously produced IgE in T cell-deficient and germ-free wild-type (wt) mice is composed of natural specificities and induced by a mechanism independent of MHC class II (MHC II) cognate help. This does not require secondary lymphoid structures or germinal center formation, although some bystander T cell-derived IL-4 is necessary. The pathway of spontaneous IgE production is not inhibited by regulatory T cells and increases with age to constitute significant serum concentrations, even in naive animals. |
