| First Author | Oguri Y | Year | 2020 |
| Journal | Cell | Volume | 182 |
| Issue | 3 | Pages | 563-577.e20 |
| PubMed ID | 32615086 | Mgi Jnum | J:304738 |
| Mgi Id | MGI:6693937 | Doi | 10.1016/j.cell.2020.06.021 |
| Citation | Oguri Y, et al. (2020) CD81 Controls Beige Fat Progenitor Cell Growth and Energy Balance via FAK Signaling. Cell 182(3):563-577.e20 |
| abstractText | Adipose tissues dynamically remodel their cellular composition in response to external cues by stimulating beige adipocyte biogenesis; however, the developmental origin and pathways regulating this process remain insufficiently understood owing to adipose tissue heterogeneity. Here, we employed single-cell RNA-seq and identified a unique subset of adipocyte progenitor cells (APCs) that possessed the cell-intrinsic plasticity to give rise to beige fat. This beige APC population is proliferative and marked by cell-surface proteins, including PDGFRalpha, Sca1, and CD81. Notably, CD81 is not only a beige APC marker but also required for de novo beige fat biogenesis following cold exposure. CD81 forms a complex with alphaV/beta1 and alphaV/beta5 integrins and mediates the activation of integrin-FAK signaling in response to irisin. Importantly, CD81 loss causes diet-induced obesity, insulin resistance, and adipose tissue inflammation. These results suggest that CD81 functions as a key sensor of external inputs and controls beige APC proliferation and whole-body energy homeostasis. |
