| First Author | Sorge RE | Year | 2015 |
| Journal | Nat Neurosci | Volume | 18 |
| Issue | 8 | Pages | 1081-3 |
| PubMed ID | 26120961 | Mgi Jnum | J:225717 |
| Mgi Id | MGI:5694271 | Doi | 10.1038/nn.4053 |
| Citation | Sorge RE, et al. (2015) Different immune cells mediate mechanical pain hypersensitivity in male and female mice. Nat Neurosci 18(8):1081-3 |
| abstractText | A large and rapidly increasing body of evidence indicates that microglia-to-neuron signaling is essential for chronic pain hypersensitivity. Using multiple approaches, we found that microglia are not required for mechanical pain hypersensitivity in female mice; female mice achieved similar levels of pain hypersensitivity using adaptive immune cells, likely T lymphocytes. This sexual dimorphism suggests that male mice cannot be used as proxies for females in pain research. |
