| First Author | Anderson MS | Year | 2005 |
| Journal | Immunity | Volume | 23 |
| Issue | 2 | Pages | 227-39 |
| PubMed ID | 16111640 | Mgi Jnum | J:100515 |
| Mgi Id | MGI:3588792 | Doi | 10.1016/j.immuni.2005.07.005 |
| Citation | Anderson MS, et al. (2005) The cellular mechanism of Aire control of T cell tolerance. Immunity 23(2):227-39 |
| abstractText | Aire promotes the tolerization of thymocytes by inducing the expression of a battery of peripheral-tissue antigens in thymic medullary epithelial cells. We demonstrate that the cellular mechanism by which Aire exerts its tolerance-promoting function is not primarily positive selection of regulatory T cells, but rather negative selection of T effector cells. Surprisingly, supplementing its influence on the transcription of genes encoding peripheral-tissue antigens, Aire somehow enhances the antigen-presentation capability of medullary epithelial cells. Thus, this transcriptional control element promotes central tolerance both by furnishing a specific thymic stromal cell type with a repertoire of self antigens and by better arming such cells to present these antigens to differentiating thymocytes. In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops. |
