| Primary Identifier | MGI:1856126 | Allele Type | Radiation induced |
| Gene | Oca2 | Inheritance Mode | Recessive |
| Strain of Origin | Not Specified | Is Recombinase | false |
| Is Wild Type | false |
| description | p25H, p-25 Harwell, recessive. This allele was neutron-irradiation-induced. Homozygotes are very similar to p6H homozygotes, except that sperm morphology differs; p25H homozygous males have a lower proportion of normal sperm (J:5219, J:5501, J:15082, J:5808). The sperm shows a loss of negative charge along the whole length of the tail (defined by the inability to stain with the positively charged colloidal iron hydroxide), suggesting that the defect in spermatogenesis may involve the Golgi apparatus and/or plasma membrane (J:11957). Females have reduced fertility. In addition, in p25H homozygotes of both sexes, the pars nervosa of the pituitary contains degenerating nerve axons (J:5508), and the hypothalamus has reduced binding capacity for estradiol-17ß (J:5219). Mutant females can generally produce a small, first litter, but the pups often die neonatally due to poor maternal behavior, which may involve improper nesting (J:49046). |
| molecularNote | Southern blot analyses using cDNA probes from the pink-eyed dilution locus show that this allele comprises an inversion of a segment of Chromsome 7 that alters the 5'end of the Oca2p gene preventing transcription of p. |
