| First Author | Eicher EM | Year | 1986 |
| Journal | Mouse News Lett | Volume | 75 |
| Pages | 29-30 | Mgi Jnum | J:14097 |
| Mgi Id | MGI:62274 | Citation | Eicher EM, et al. (1986) Allelism of Den and Re. Mouse News Lett 75:29-30 |
| abstractText | Full text of MNL contribution: d. Allelism of Den and Re. We have located the dominant mutation denuded, original gene symbol Den (MNL2:28), on Chromosome 11 and suggest that it is an allele of Re. We propose that the gene name remain denuded and the gene symbol change to Re<den>. A backcross (vt +/+ Den X vt +/vt +) with vestigial tail (vt) produced 48 vt +, 47 + Den, 9 + +, and 21 vt Den, indicating that Den was located on Chr 11. In order to define more accurately the position of Den on Chr 11, we established the backcross: Den +/+ Re X + +/+ +. Out of a total of 504 offspring born, 249 were classified as Den + and 255 were classified as + Re. Our classification of these mice as either Den or Re and not Den Re were based on the different phenotypes that each mutation produces when separate or combined. Homozygous and heterozygous Re mice have a waved coat and curly whiskers. Mice that are Den/+ are nearly nude and have normal whiskers, whereas homozygous Den/Den mice are nude and have normal whiskers. The Fl parents that were Den +/+ Re resembled homozygous Den mice in that they were nude and Re mice in that they had curly whiskers. Neither the phenotype of the Fl parent nor the normal (+ +) phenotype was observed in the 504 backcross offspring. We conclude that Den is either an allele of Re or is closely linked to it. We favor defining Den as an allele of Re. (Eicher and D. Varnum) |
