| First Author | Snell GD | Year | 1968 |
| Journal | Mouse News Lett | Volume | 39 |
| Pages | 28 | Mgi Jnum | J:13486 |
| Mgi Id | MGI:61673 | Citation | Snell GD, et al. (1968) Re. Mouse News Lett 39:28 |
| abstractText | Full text of MNL contribution: G.D. Snell and H.P. Bunker. New Mutation: A male resembling naked was discovered in the congenic line B10.129 (11 M) in 1964. The mutation is a dominant and is maintained by mating heterozgous males to normal female littermates. Two tested homozygous males have been produced and both were healthy and virile. The mutants can be distinguished by folds of body skin at about one week of age. Then the coat grows normally until about four weeks of age when it becomes sparse on the head and neck. Regrowth may occur, but after six weeks hair loss is progressive. Old animals are almost naked and usually become blind by six months. The mutation was tested for linkage with Ca and segregated independently. It is therefore not N. Since it is viable when homozygous it cannot be identical with repeated epilation (Er) which is a homozygous lethal. That it is determined by a different locus than Er was shown by a backcross in which it was possible, though with difficulty, to distinguish four genotypes. The mutation has been tested for linkage with the following genes in addition to Ca: Miwh, Wv, T, Ra, Os, and Pt. No linkage has been found, and it is currently being tested with Sl. The suggested symbol for this mutation, called denuded, is Den. |
