| First Author | Fuccillo M | Year | 2006 |
| Journal | Cereb Cortex | Volume | 16 Suppl 1 |
| Pages | i96-102 | PubMed ID | 16766714 |
| Mgi Jnum | J:174118 | Mgi Id | MGI:5051904 |
| Doi | 10.1093/cercor/bhk023 | Citation | Fuccillo M, et al. (2006) Removal of Pax6 partially rescues the loss of ventral structures in Shh null mice. Cereb Cortex 16 Suppl 1:i96-102 |
| abstractText | Pax6 and Gli3 are dorsally expressed genes that are known to antagonize sonic hedgehog (Shh) activity. We have previously shown that dorsoventral patterning defects seen in Shh(-/-) mutants are rescued in Shh(-/-);Gli3(-/-) compound mutants. Here we investigate if the loss of Pax6 can also ameliorate defects seen in Shh(-/-) mutants. In support of this notion, we observe that the fusion of the cerebral vesicles seen in Shh(-/-) mutants is partially corrected in E12.5 Shh(-/-);Pax6(-/-) compound mutants. Investigation of pan-ventral markers such as Dlx2 also shows that, unlike Shh(-/-), a broad domain of expression of this gene is observed in Shh(-/-);Pax6(-/-) mice. Interestingly, we observe that while the expression of ER81 in the ventral telencephalon is expanded, the expression of Ebf1 is lost. This suggests that the rescued ventral domain observed in Shh(-/-);Pax6(-/-) mice is the dorsal lateral ganglionic eminence region. With regard to dorsal telencephalic patterning, we also observe rescue of the pallial-subpallial boundary, as well as a partial rescue of the dorsal midline. Together, our findings are consistent with Pax6 function being required for aspects of Gli3-mediated telencephalic patterning. |
